Cavanagh, J. ed.
Protein NMR Spectroscopy 2nd ed.
タンパク質 NMR 分光分析 第2版
Academic Press 2006.11
885 pp.(H)
ISBN 0-12-164491-x
12,400円
Contents
* タンパク質の NMR 分光分析法の入門書として高い評価を得た1996年の初版刊行から、まもなく10年が経ち、その間 NMR 分光法は長足の進歩を遂げました。本書は NMR 分光分析研究の進展をうけ、大幅な改訂をおこなった Protein NMR Spectroscopy の第2版です。
* スピン緩和理論の新モデル、構造変化、分析機器、信号取得、勾配一貫性、多次元分光法、タンパク質構造計算など、最新の研究成果を盛り込んでおり、大学院生からタンパク質の NMR の研究者まで広く利用できる一冊です。また、初版が学生のための入門書として広く利用されたことをうけ、第2版には各章末の演習問題を収録し、教科書としてより利用しやすい構成となっています。
Preliminary Table of Contents / 1. Classical NMR Spectroscopy / 2. Theoretical Description of NMR Spectroscopy / 3. Experimental Aspects of NMR Spectroscopy / 4. Multi-Dimensional NMR Spectroscopy / 5. Relaxation and Dynamic Processes / 6. Experimental 1H NMR Methods / 7. Heteronuclear NMR Experiments / 8. Experimental NMR Relaxation Methods / 9. Larger Proteins and Molecular Interactions / 10. Sequential Assignment, Structure Determination and Other Applications. *
Drenth, J.
Principles of Protein X-Ray Crystallography 3rd ed.
Springer-Verlag 2007.1
332 pp. (H)
ISBN 0-387-33334-7
12,400円
Contents
* X線結晶解析法は、タンパク質や高分子の構造解明において極めて重要な手法である。生化学や生物物理学から医薬品開発、バイオテクノロジーまで、タンパク質の重要性がますます高まるなか、X線回折はタンパク質の解析に欠かせないツールであると認識さえれている。
* このたびの改訂第３版では、X線結晶解析学への多大な貢献で世界的に名高いDr. Jan DrenthがX線結晶解析法について最新かつ技術的に厳密な説明を展開している。
Prefaces.- 1 Crystallizing a Protein.- 2.X-Ray Sources and Detectors.- Crystals.- 3.The Theory of X-Ray Diffraction by a Crystal.- 4.Average Reflection Intensity and Distribution of Structure Factor Data.- 5.Special Forms of the Structure Factor.- 6.The Solution of the Phase Problem by the Isomorphous Replacement Method.- 7.Phase Improvement.- Anomalous Scattering in the Determination of the Protein Phase Angles and the Absolute Configuration.- 8.Molecular Replacement.- 9.Direct Methods.- 10.Laue Diffraction.- 11.Refinement of the Model Structure.- 12.The Combination of Phase Information.- 13.Checking for Gross Errors and Estimating the Accuracy of the Structural Model.- 14.Tips and Tricks in Protein Crystallization/ Appendices/ References/ Index/
About this textbook : X-ray crystallography has long been a vital method for studying the structure of proteins and other macromolecules. As the importance of proteins continues to grow, in fields from biochemistry and biophysics to pharmaceutical development and biotechnology, many researchers have found that a knowledge of X-ray diffraction is an indispensable tool. In this new edition of his essential work, Dr. Jan Drenth, recognized internationally for his numerous contributions to crystallographic research, has provided an up-to-date and technically rigorous introduction to the subject. Principles of Protein X-ray Crystallography provides the theoretical background necessary to understand how the structure of proteins is determined at atomic resolution. It is intended to serve as an introduction for graduate students, postdoctoral researchers, and established scientists who want to use protein crystallography in their own endeavors, or need to understand the subject in order to critically evaluate the literature. New additions to the book include a section on twinning, an additional chapter on crystal growth and a discussion of single-wavelength anomalous dispersion (SAD). *
Zu, Y. et al.
Computational Methods for Protein Structure Prediction and Modeling Vol.1
Basic Characterization
タンパク質構造予測とモデリングの計算手法
Springer-Verlag 2007.
394 pp.(H)
ISBN 0-387-33319-3
19,400円
Contents
* 第1巻は既知のタンパク質構造の基礎的な特性評価と、タンパク質の配列情報からの構造予測を解説します。 * 全11章では、モデリングや力場、分類、計算手法、構造予測などの内容をカバーし、この分野の概要をまとめています。各章はそれぞれ完結したレビューとなっており、1)問題の定義と歴史的流れ、2)問題の数式化、3)計算法とアルゴリズム、4)パフォーマンス、5)既存のソフトウェアパッケージ、6)長所、注意点、難問、今後の研究の方向性から構成されています。
Contents: Part 1.Modeling Protein Structures/Part 2.Empirical Force Fields/ Part 3.Knowledge-based Energy Functions for Computational Studies of Proteins / *
Xi, Y. et al.
Computational Methods for Protein Structure Prediction and Modeling Vol.2
Structure Prediction
タンパク質構造予測とモデリングの計算手法
Springer-Verlag 2006.10
320 pp.(H)
ISBN 0-387-33321-5
22,100円
Contents
* 第2巻はタンパク質の構造予測がテーマであり、タンパク質スレッディング、De novoモデリング、膜タンパクやタンパク質複合体への応用、構造に基づく薬品設計、システム問題としての構造予測などを収録しています。また付録ではタンパク質構造に関わる生物学と化学の基礎、構造インフォマティクスの基礎計算機科学、そして前提知識として求められる数学と統計学を概説しています。
Contents: 1.Homology-based structure modeling/ 2.Fold recognition of globular proteins/ 3.Ab initio protein structure prediction/ 4.Structure prediction of membrane proteins/ 5.Structure prediction of protein complexes/ 6.Protein structure-based Drug Design/ 7.Structure prediction as a systems problem/ 8.Resources for protein structure/function characterization/ *
Doublie, S.
Macromolecular Crystallography Protocols Vol.1
Preparation and Crystallization of Macromolecules
Humana Press 2006.12
312 pp.(H)
ISBN 1-58829-292-4
13,600円
Contents
1. A Generic Method for the Production of Recombinant Proteins in Escherichia coli Using a Dual Hexahistidine-Maltose-Binding Protein Affinity Tag/ 2. Cloning, Production, and Purification of Proteins for a Medium-Scale Structural Genomics Project/ 3. Baculoviral Expression of an Integral Membrane Protein for Structural Studies/ 4. Protein Engineering/ 5. Production of Selenomethionyl Proteins in Prokaryotic and Eukaryotic Expression Systems/ 6. How to Use Dynamic Light Scattering to Improve the Likelihood of Growing Macromolecular Crystals/ 7. Screening and Optimization Methods for Nonautomated Crystallization Laboratories/ 8. Improving Marginal Crystals/ 9. Optimization Techniques for Automation and High Throughput/ 10. Three-Dimensional Crystallization of Membrane Proteins/ 11. Crystallization of ProteinﾐDNA Complexes/ 12. Preparation and Crystallization of RNA/ 13. Crystallization of RNA-Protein Complexes/
* Macromolecular Crystallography Protocols, now in two volumes, examines major developments that have occurred since publication of the acclaimed first edition nearly a decade ago. Volume 1, Preparation and Crystallization of Macromolecules and Volume 2, Structure Determination, explore recent advances that have accelerated the pace of structural determination and made crystallography accessible to a broader range of investigators. *
Doublie, S.
Macromolecular Crystallography Protocols Vol.2
Structure Determination
Humana Press 2006.12
400 pp.(H)
ISBN 1-58829-902-3
16,200円
Contents
1. Cryocrystallography of Macromolecules: Practice and Optimization/ 2. Determination of Reaction Intermediate Structures in Heme Proteins/ 3. Annealing Macromolecular Crystals/ 4. First Analysis of Macromolecular Crystals: Biochemistry and X-Ray Diffraction/ 5. X-Ray Data Collection From Macromolecular Crystals/ 6. Characterizing a Crystal From an Initial Native Dataset/ 7. Molecular Replacement/ 8. Phase Determination Using Halide Ions/ 9. The Same But Different: Isomorphous Methods for Phasing and High-Throughput Ligand Screening/ 10. Substructure Determination in Multiwavelength Anomalous Diffraction, Single Anomalous Diffraction, and Single Isomorphous Replacement With Anomalous Scattering Data Using Shake-and-Bake/ 11. Substructure Determination in Isomorphous Replacement and Anomalous Diffraction Experiments/ 12. Automated Structure Solution With autoSHARP/ 13. Introduction to Macromolecular Refinement / 14. Quality Control and Validation/ 15. Crystallographic Software: A Sustainable Resource for the Community/ *
Marechal, Y.
The Hydrogen Bond and the Water Molecule
The Physics and Chemistry of Water, Aqueous and Bio-Media
Elsevier Science Ltd. 2006.12
332 pp. (H)
ISBN 0-444-51957-2
25,000円
Contents
1. The hydrogen bond: formation, thermodynamic properties, classification/ 2. Geometrical properties of H-bonds and H-bonded organized supramolecular structures/ 3. Methods to observe and describe H-bonds Calorimetry/ 4. Infrared spectroscopy of H-bonded systems: experimental point of view/ 5. Infrared spectroscopy of H-bonded systems: theoretical descriptions/ 6. Reactivity of H-bonds: transfers of protons and of H-atoms/ 7. H/D isotopic substitution in H-bonds/ 8. The H2O molecule in water vapour and ice/ 9. The H2O molecule in liquid water/ 10. The water molecule in (bio)macromolecules/ 11. Observing the water molecule/ 12. Conclusion: the H-bond, the water molecule and life/
* The most simple water molecular, H2O, is a fascinating but poorly understood molecule. Its unique ability to attract an exceptionally large number of hydrogen bonds induces the formation of a dense "hydrogen bond network" that has the potential to modify the properties of the surrounding molecules and their reactivities. The crucial role that water molecules play is described in this book. *
132-30 登録日 07.05.06
