Giuliani, A. & Rinaldi, A. C. ed.
Antimicrobial Peptides
Methods and Protocols
（抗菌ペプチド）
Humana Press 2010.1
409 pp.(H)
ISBN 1-60761-593-2
16,700円
Contents
1. Antimicrobial Peptides in Frog Skin Secretions/ 2. Purification of Antimicrobial Peptides from Human Skin/ 3. Strategies for the Isolation and Characterization of Antibacterial Lantibiotics/ 4. Expression and Purification of Recombinant -Defensins and -Defensin Precursors in Escherichia coli/ 5. Production of Recombinant Antimicrobial Peptides in Bacteria/ 6. Methods for Building Quantitative Structure-Activity Relationship (QSAR) Descriptors and Predictive Models for Computer-Aided Design of Antimicrobial Peptides/ 7. Synthesis and Thermodynamic Characterization of Small Cyclic Antimicrobial Arginine and Tryptophan-Rich Peptides with Selectivity for Gram-Negative Bacteria/ 8. Synthesis of Antimicrobial Peptides Using the SPOT Technique/ 9. High-Throughput Screening for Antimicrobial Peptides Using the SPOT Technique/ 10. Antimicrobial Peptides: The LPS Connection/ 11. Binding and Permeabilization of Model Membranes by Amphipathic Peptides/ 12. Comparing Bacterial Membrane Interactions of Antimicrobial Peptides and Their Mimics/ 13. Dynamic Transitions of Membrane-Active Peptides/ 14. Solid-State NMR Investigations of Membrane-Associated Antimicrobial Peptides/ 15. Use of Atomic Force Microscopy as a Tool to Understand the Action of Antimicrobial Peptides on Bacteria/ 16. Fluorescence and Electron Microscopy Methods for Exploring Antimicrobial Peptides Mode(s) of Action/ 17. Molecular Simulations of Antimicrobial Peptides/ 18. Computer-Based Analysis, Visualization, and Interpretation of Antimicrobial Peptide Activities/ 19. Potential Therapeutic Application of Host Defense Peptides/ 20. Therapeutic Potential of HDPs as Immunomodulatory Agents/ 21. Assay Systems for Measurement of Anti-inflammatory Activity/ 22. Ex Vivo Skin Infection Model/ 23. Measuring Antimicrobial Peptide Activity on Epithelial Surfaces in Cell Culture/ 24. Antimicrobial and Antibiofilm Activity of Quorum Sensing Peptides and Peptide Analogues Against Oral Biofilm Bacteria/ 25. Characterization of the Leishmanicidal Activity of Antimicrobial Peptides/ Index/ *
Vinks, A. et al. ed.
Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics
抗菌薬物の動態学と力学原点
Springer-Verlag 2010.3
400 pp.(H)
ISBN 0-387-75612-4
16,200円
Contents
Section I: Basic Concepts and Principles: 1. Introduction to Pharmacodynamics and micrbiology/ 2. In vitro and animal PK/PD model/ 3. MIC and breakpoints/ 4. Principles of applied PK/PD modeling/ 5. Population Pk/PD modeling and its applications to antimicrobials/ 6. Drug resistance and Drug-drug combinations/ Section II: Clinical: 7. Aminoglycosides/ 8. Beta-lactam antibiotics including continuous infusion/ 9. Macrolides/ 10. Glycopeptides/ 11. Quinolones/ 12. Other/ Index/
* Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. *
Gherbawy, Y. & Voigt, K. ed.
Molecular Identification of Fungi
Springer-Verlag 2010.3
501 pp.(H)
ISBN 3-642-05041-7
27,400円
Contents
1. Fungal pathogens of plants in the Homogocene/ 2. Molecular techniques for classification and diagnostics of plant pathogenic Oomycota/ 3. Plasmodiophorids: The challenge to understand soil-borne, obligate biotrophs with a multiphasic life cycle/ 4. Applications of molecular markers and DNA sequences in identifying fungal pathogens of cool season grain legumes/ 5. Quantitative detection of fungi by molecular methods: A case study on Fusarium/ 6. DNA-based tools for the detection of Fusarium spp. pathogenic on maize/ 7. Recent Advances in Molecular Detection and Diversity of Fusarium oxysporum/ 8. Molecular chemotyping of Fusarium graminearum, F. culmorum and F. cerealis isolates from Finland and Russia/ 9. Molecular characterization and diagnosis of Macrophomina phaseolina - a charcoal rot fungus/ 10. Molecular diagnosis of ochratoxigenic fungi/ 11. Molecular barcoding of microscopic fungi with emphasis on the mucoralean genera Mucor and Rhizopus/ 12. Advances in detection and identification of wood rotting fungi in timber and standing trees/ 13. Molecular diversity and identification of endophytic fungi/ 14. Molecular identification of anaerobic rumen fungi/ 15. New approaches in fungal DNA preparation from whole blood and subsequent pathogen detection via multiplex PCR/ 16. Classification of yeasts of the genus Malassezia by sequencing of the ITS and D1/D2 regions of DNA/ 17. DNA-based detection of human pathogenic fungi: dermatophytes, opportunists and causative agents of deep mycoses/ 18. Applications of loop-mediated isothermal amplificaton methods (LAMP) for identification and diagnosis of mycotic diseases: Paracoccidioidomycosis and Ochroconis gallopava infection/ 19. Identification of the genus Absidia (Mucorales, Zygomycetes), a comprehensive taxonomic revision/ 20. Molecular characters of zygomycetous Fungi/ Index/
* This timely book links scientists from different parts of the world who are interested in the molecular identification of fungi combined with the exploration of the fungal biodiversity in different ecosystems. It provides a compendium for scientists who rely on a rapid and reliable detection of fungal specimens in environmental as well as clinical resources in order to ensure the benefit of industrial and clinical applications. *
Villa, T. G. & Crespo, P. V. ed.
Enzybiotics
Antibiotic Enzymes as Drugs and Therapeutics
John Wiley & Sons 2010.1
284 pp.(H)
ISBN 0-470-37655-4
11,400円
Contents
1. Enzybiotics and Their Potential Applications in Medicine/ 2. Advantages and Disadvantages in the Use of Antibiotics or Phages as Therapeutic Agents/ 3. Enzybiotics as Selective Killers of Target Bacteria/ 4. Phylogeny of Enzybiotics/ 5. Bacteriophage Lysing: The Ultimate Enzybiotic/ 6. Bacteriophage Holins and Their Membranedisrupting Activity/ 7. Anti-Ataphylococcal Lytic Enzymes/ 8. Membrane-Targeted Enzybiotics/ 9. Design of Phage Cocktails for Therapy from a Host Range Point of View/ 10. Identifying Phage Lytic Enzymes : Past, Present, and Future/ 11. Use of Genetically Modified Phages to Deliver Suicidal Genes to Target Bacteria/ Concluding Remarks: The Future of Enzybiotics/ Index/
* Enzybiotics is a promising way of fighting bacterial or fungal infectious diseases by using viruses or viral-derived lysins. Drawing from the fields of medicinal chemistry, microbiology, genetics, and biochemistry, this book presents the state of the science in enzybiotics research, fully exploring its emerging therapeutic applications. *
Varela, A. & Ibanez, J. ed.
Medicinal Plants
Classification, Biosynthesis and Pharmacology
Nova Science Pub. 2010.4
(H)
ISBN 1-60876-027-8
17,400円
Contents
1.Biological Effects of β-carotene/ 2.Native Medicinal Plants used in the Ethnomedicine of the Cordoba Hills in Central Argentina: Relevance and Interest for Primary Health Care and Conservation/ 3.Gastroprotective Triterpenoids: Pharmacological Mechanism/ 4.Biosyntheses and Bioactivities of Flavonoids in the Medicinal Plant Scutellaria Baicalensis/ 5.Management of Diabetes with Diet and Plant-Derived Drugs/ 6.Biomolecules with Anti-Mycobacterial Activity/ 7.Metal Concentrations in Taiwanese Health Food, Angelica Keiskei, Other Products and Maximum Daily Intake/ 8.Ethnobotany and Experimental Pharmacology of Echinodorus Grandiflorus (chapeu de couro)/ 9.Non-Invasive Near Infrared Spectroscopic Techniques for the Characterization of Medicinal Plants and their Constituents/ 10.What is the Future of Phytotherapy? A Commentary/ 11.Quality Control of Polysaccharides From Medicinal Plants and Fungi/ Index/
* Plants have been the main source of medicines since ancient times. Practically all human societies have utilized plants not only as sources of nutrition but also as therapy against diseases and ailments. Considering the fact that the synthesis of a pharmaceutical requires an enormous investment of research and money, the discovery of useful medicinal plants which have been used for millennia is very appealing. This book examines Scutellaria baicalensis, one of the most widely used medicinal plants whose roots have been used for anti-inflammation, anticancer, decreasing blood pressures, reducing the total cholesterol level and treating bacterial and viral infections. *
de la Rosa, L. A. et al. ed.
Fruit and Vegetable Phytochemicals
Chemistry, Nutritional Value and Stability
Blackwell Pub. 2010.1
384 pp.(H)
ISBN 0-8138-0320-9
21,500円
Contents
1. The Contribution of Fruit and Vegetable Consumption to Human Health/ 2. Phenolic Compounds: Chemistry and Occurrence in Fruits and Vegetables/ 3. Synthesis and Metabolism of Phenolic Compounds/ 4. Enzymatic and Non-Enzymatic Degradation of Polyphenols/ 5. Chemistry of Flavonoids/ 6. Flavonoids and their Relation to Human Health/ 7. Chemistry, Stability and Biological Actions of Carotenoids/ 8. Dietary Fiber and Associated Antioxidants in Fruit And Vegetables/ 9. Emerging Technologies Used for the Extraction of Phytochemicals from Fruits, Vegetables and Other Natural Sources/ 10. Methods of Analysis of Antioxidant Capacity of Phytochemicals/ 11. Phytochemical Changes in the Postharvest and Minimal Processing of Fresh Fruits and Vegetables/ 12. Quality Loss of Fruits and Vegetables Induced by Microbial Growth/ Index/ *
Buss, A. D. ed.
Natural Product Chemistry for Drug Discovery
医薬品開発のための天然産物化学
Royal Society of Chemistry 2009.12
458 pp.(H)
ISBN 0-85404-193-1
25,000円
Contents
1. Natural Products as Drugs and Leads to Drugs: The Historical Perspective/ 2. Chemical Space and the Difference Between Natural Products and Synthetics/ 3. Mechanism of Action Studies/ 4. The Convention on Biological Diversity and its Impact on Natural Product Research/ 5. Plants: Revamping the Oldest Source of Medicines with Modern Science/ 6. Macromarines: A Selective Account of the Potential of Marine Sponges, Molluscs, Soft Corals and Tunicates as a Source of Therapeutically Important Molecular Structures/ 7. Microorganisms: Their Role in the Discovery and Development of Medicines/ 8. Advances in Biological Screening for Lead Discovery/ 9. Advances in Instrumentation, Automation, Dereplication and Prefractionation/ 10. Natural Product Combinatorial Biosynthesis: Promises and Realities/ 11. A Snapshot of Natural Product-Derived Compounds in Late Stage Clinical Development at the End of 2008/ 12. From Natural Product to Clinical Trials: NPI-0052 (Salinosporamide A), a Marine Actinomycete-Derived Anticancer Agent/ 13. From Natural Product to Clinical Trials: Bevirimat, a Plant-Derived Anti-AIDS Drug/ 14. Daptomycin/ 15. Micafungin/ Index/
* Natural Product Chemistry for Drug Discovery provides a comprehensive summary of where natural product chemistry is today in drug discovery. The book covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products. *
Mander, L. & Liu, H.- W.
Comprehensive Natural Products II (10 Volumes Set)
天然産物全書 全１０巻
Elsevier 2010.4
7388 pp.(H) in 10Vols.
ISBN 0-08-045381-3
433,000円
Contents
1. Natural Products Structural Diversity-I Secondary Metabolites: Organization and Biosynthesis/ 2. Natural Products Structural Diversity-II Secondary Metabolites: Sources, Structures and Chemical Biology/ 3. Development & Modification of Bioactivity/ 4. Chemical Ecology/ 5. Amino Acids, Peptides and Proteins/ 6. Carbohydrates, Nucleosides & Nucleic Acids/ 7. Cofactors/ 8. Enzymes and Enzyme Mechanisms/ 9. Modern Methods for the Investigation of Natural Products/ Index/
* This work presents a definitive interpretation of the current status of and future trends in natural products-a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work ( 1999). *
172-43 登録日 10.04.13
