Guarente, L. P. et al. ed.
Molecular Biology of Aging
Cold Spring Harbor Laboratory 2008.
610 pp.(H)
ISBN 0-87969-824-1
16,400円
Contents
1. The Human Mitochondrion and Pathophysiology of Aging and Age-related Diseases/ 2. Sirtuins: A Universal Link between NAD, Metabolism, and Aging/ 3. Calorie Restriction in Lower Organisms/ 4. Evolutionary Theory in Aging Research/ 5. An Overview of the Biology of Aging: A Human Perspective/ 6. p53, Cancer, and Longevity/ 7. Aging Processes in Caenorhabditis elegans/ 8. Cellular Senescence: A Link between Tumor Suppression and Organismal Aging?/ 9. Genome-wide Views of Aging Gene Networks/ 10. Aging in Mammalian Stem Cells and Other Self-renewing Compartments/ 11. Yeast, A Feast: The Fruit Fly Drosophila as a Model Organism for Research into Aging/ 12. DNA Repair and Aging/ 13. Extended Life Span in Mice with Reduction in the GH/IGF-1 Axis/ 14. Alzheimer’s Disease: Genetics, Pathogenesis, Models, and Experimental Therapeutics/ 15. How Does Calorie Restriction Increase the Longevity of Mammals?/ 16. Determination of Aging Rate by Coordinated Resistance to Multiple Forms of Stress/ 17. Molecular Mechanisms of Aging: Insights from Budding Yeast/ 18. Genetics of Exceptional Longevity/ 19. Mammalian Metabolism in Aging/ 20. Telomeres and Telomerase in Aging and Cancer/ Index/ *
Whitbourne , S. K. ed.
Adult Development and Aging 3rd ed.
Biopsychosocial Perspectives
John Wiley & Sons 2007.12
496 pp.(H)
ISBN 0-470-11860-1
16,500円
Contents
1. Themes and Issues in Adult Development and Aging/ 2. Models of Development: Nature and Nurture in Adulthood/ 3. The Story of Adult Development and Aging: Research Methods/ 4. Physical and Sensory Changes in Adulthood and Old Age/ 5. Health and Prevention/ 6. Basic Cognitive Functions: Information Processing, Attention, and Memory/ 7. Language, Problem Solving, and Intelligence/ 8. Personality and Patterns of Coping/ 9. Relationships/ 10. Work, Retirement, and Leisure Patterns/ 11. Mental Health Issues and Treatment/ 12. Long-Term Care/ 13. Death and Dying/ 14. Successful Aging and Creativity/ Index/
* This completely updated third edition guides readers through the art of successful aging. Leading aging expert Susan Krauss Whitbourne focuses on how individuals can take an active role in their aging processes and make it a rewarding developmental period, filled with vitality and creativity. Written in a more conversational style, the book combines research and applied perspectives, providing an even balance between biological, social, cognitive, and personality theory as it relates to adulthood and aging. *
Morewitz, S. J. & Goldstein, M.
Aging and Chronic Disorders
Springer-Verlag 2007.8
236 pp.(H)
ISBN 0-387-70856-1
6,400円
Contents
1. Chronic Disorders in an Aging Population: Epidemiology/ 2. Elders and Health Care Utilization and Costs/ 3. Chronic Disease and Quality of Life in Older Adults/ 4. Psychological Problems in the Elderly/ 5. Cognitive Changes in Older Adults/ 6. Seniors with Diabetes Mellitus/ 7. Rheumatoid Arthritis, Osteoarthritis, Osteoporosis,Fibromyalgia, and Low Back Pain in Older Adults/ 8. Cardiovascular Disease in the Elderly/ 9. Seniors with Cancer/ References/ About the Authors/ Author Index/ Subject Index/ *
Pawelec, G. ed.
Immunosenescence
Springer-Verlag 2008.2
194 pp.(H)
ISBN 0-387-76840-8
19,200円
Contents
1. Immune Risk Phenotypes and Associated Parameters in Very Old Humans: A Review of Findings in the Swedish NONA Immune Longitudinal Study/ 2. Scoring of Immunological Vigor: Trial Assessment of Immunological Status as a Whole for Elderly People and Cancer Patients/ 3. Remodelling of the CD8 T-Cell Compartment in the Elderly: Expression of NK Associated Receptors on T-Cells Is Associated with the Expansion of the Effector Memory Subset/ 4. Telomeres, Telomerase and CD28 in Human CD8 T-cells: Effects on Immunity during aging and HIV infection/ 5. A matter of life and death of t-lymphocytes in immunosenescence/ 6. T-Cell Signalling, a Complex Process for T-Cell Activation Compromised with Aging: When Membrane Rafts Can Simplify Everything/ 7. Immunosenescence, Thymic Involution and Autoimmunity/ 8. Autoimmune Diseases, Agingand the CD4+ Lymphocyte: Why Does Insulin-Dependent Diabetes Mellitus Start in Youth, but Rheumatoid Arthritis Mostlyat Older Age?/ 9. Role of Chemokines and Chemokine Receptors in Diseases of Ageing/ 10. The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly/ 11. Zinc and the Altered Immune System in the Elderly/ 12. Zinc-Binding Proteins and Immunosenescence: Implications as Biological and Genetic Markers/ 13. Immunogenetics of Aging/ 14. The genetics of innate immunity and inflammation in ageing, Age-related diseases and longevity/ 15. SELDI Proteomics Approachto Identify Proteins Associated with T-Cell Clone Senescence/ Index/
* The majority of the papers collected in this volume therefore address not only the mechanisms responsible for immune ageing in humans but consider what might be accomplished to redress the erosion of immune competence with age. The first problem facing the gerontologist investigating human ageing is their longevity: most studies are conducted in a cross-sectional manner, in which parameters of interest in elderly cohorts are compared to young controls. However, the ageing trajectories of people now 80 years old, born at the beginning of the 20th century, will have been very different in mostly unidentifiable ways from those born towards the end of that century. *
Duque, G. & Kiel, D. P. ed.
Osteoporosis in Older Persons
Pathophysiology and Therapeutic Approach
Springer-Verlag 2008.1
192 pp.(H)
ISBN 1-84628-515-1
23,400円
Contents
1.Biology of Bone/ 2.Aging and Bone/ 3.Calciotropic Hormones/ 4.Sex Steroids and Aging Bone/ 5.Animal Models for Senile Osteoporosis/ 6.Senile Osteoporosis as a Geriatric Syndrome/ 7.Genetics of Osteoporosis in Older Age/ 8.Fracture Epidemiology Among Individuals 75+/ 9.Falls as a Geriatric Syndrome: How to Prevent Them? How to Treat Them?/ 10.Non-Pharmacological Treatments for Falls and Fractures/ 11.Medical Treatment of Age-Related Osteoporosis: Present and Future/ 12.Treatment of Osteoporosis in Long-Term Care/ 13.Fracture Care in the Elderly/ Index/ *
Marin-Garcia, J.
Aging and the Heart
A Post-Genomic View
Springer-Verlag 2007.12
574 pp.(H)
ISBN 0-387-74071-6
21,400円
Contents
Section I: Introduction to A Post-Genomic View of Aging and the Aging Heart/ Post-Genomic View of Aging: Definitions, Theories and Observations/ Overview of Cardiovascular Aging/ Section II: Methodologies, Cardiac Phenotypes And Adaptation: Molecular and Cellular Methodologies/ Molecular And Cellular Phenotypes of Cardiac Aging/ Section III: Aging of the Cardiovasculature and Related Systems: Aging of the Vasculature/ Aging of Cardiovascular-Related Systems/ Section IV: Cardiovascular Diseases in Aging: Cardiomyopathy and Heart Failure in Aging/ Atherosclerosis, Hypertension and Aging/ Metabolic Syndrome, Diabetes and Cardiometabolic Risks in Aging/ Gender and Cardiovascular Aging/ Cardiac Dysrhythmias and Channelopathies in Aging/ Section V: Genetics: Genetics of Life Span: Lessons from Model Organisms/ Profiling the Aging Cardiovascular System: Transcriptional, Proteomic, SNP, Gene Mapping and Epigenetics Analysis/ Section VI: Therapies: Translational Research: Pharmacogenomics, Gene and Cell-Based Therapy in the Aging Cardiovascular System/ Nutrition and Exercise in Cardiovascular Aging: Metabolic and Pharmacological Interventions/ Section VII. The Future of Aging Research: Aging and the Frontier ahead/ Glossary/ Index/
* Cardiac aging, like aging in general, is a complex process. Numerous cellular and molecular changes contribute to the expression of the multiple phenotypes of aging, "the different faces" of cardiac aging. In this book, the genetic and molecular basis of cardiovascular aging will be discussed. In addition, a comprehensive assessment of the bioenergetic changes that occur in human and animal models of cardiac aging as well as current diagnostic and future therapeutic modalities will be undertaken. Jose' Marin-Garcia is Director, The Molecular Cardiology and Neuromuscular Institute, Highland Park, New Jersey. *
Baudisch, A.
Inevitable Aging?
Contributions to Evolutionary-Demographic Theory
（避けられないエイジング？）
Springer-Verlag 2008.2
170 pp.(H)
ISBN 3-540-76655-3
12,600円
Contents
1. Introduction/ Part I: Hamilton: 2. Hamilton's Indicators of the Force of Selection/ 3. Further Challenges/ Part II: Optimization Models: 4. Optimization Models Based on Size/ 5. An Optimization Model Based on Vitality/ 6. Directions for Research/ A: Vitality Model - Appendix: A.1 Solving Differential Equations/ A.2 Proof of Non-Existence of an Optimal Solution for a Special Case/ A.3 The Algorithm/ References/ Index/
* Honored by the Max Planck Society with the Otto Hahn Medal 2007 for outstanding scientific achievements
* Aging is inevitable: this is gerontological dogma. And humans do inevitably grow old, which is probably why it seems so unlikely to us that other forms of life could escape aging. Escaping aging is not escaping death. Death is an inherent part of life, and it can strike any time. But the question is whether death necessarily becomes more likely as life proceeds. And it does not. The theoretical results in this monograph indicate that life provides alternative strategies. While some organisms will deteriorate over adult ages, for others mortality appears to fall or remain constant, at least over an extended period of life after reproductive maturity. This is empirically observed especially for�Aspecies that keep on growing during adult ages. Perhaps the diversity of aging matches the diversity of life. My thesis, the central insight of this monograph, is: to deeply understand why some species age it is necessary to understand why other species do not. *
238-19 登録日 08.04.13
