Allison , W. & Scheffler , I.
Mitochondrial Function Part A
Mitochondrial Electron Transport Complexes and Reactive Oxygen Species
(Methods in Enzymology Vol. 456)
Academic Press 2009.4
450 pp.(H)
ISBN 0-08-087776-1
19,600円
Contents
Part A: Electron Transport Complexes: 1. Visualizing functional flexibility by three dimensional electron microscopy: reconstructing Complex I of the mitochondrial respiratory chain/ 2. Electron tomography of the mitochondrion/ 3. Mid-IR vibrational studies of complex I/ 4. Electron transfer in respiratory complexes resolved by an ultra-fast freeze-quench approach/ 5. Use of ruthenium photooxidation techniques to study electron transfer in the cytochrome bc1 complex/ 6. Use of ruthenium photoreduction techniques to study electron transfer in cytochrome oxidase/ 7. Mass spectrometric characterization of subunits of electron transfer complexes that are encoded in the mitochondrial genome/ 8. The assembly of respiratory chain complexes studied by GFP-tagged subunits/ 9. Two-dimensional native electrophoresis for functional assays of mitochondrial complexes/ 10. Reliable assay for complex I in human blood lymphocytes and skin fibroblasts/ 11. Purification of the cytochrome c reductase/cytochrome c oxidase supercomplex of yeast mitochondria/ 12. Supercomplex organization of the yeast mitochondrial respiratory chain complexes and the ADP/ATP carrier proteins/ 13. Role of cysteine desulfurase Nfs1 in human mitochondrial Fe-S protein biogenesis/ 14. Identification and properties of the novel 2Fe-2S center in the outer membrane protein, mitoNEET/ 15. Nucleotide-dependent iron-sulfur cluster biogenesis in mitochondria/ 16. Preparation of samples for EPR and Mossbauer spectroscopy of intact Saccharomyces cerrevisiae mitochondria/ 17. Fluorescence correlation spectroscopy to probe mitochondrial mobility and intramatrix protein diffusion/ 18. Characterization of alternative complex I of Plasmodium falciparum mitochondria/ 19. Analysis of respiratory chain complex assembly using radiolabeled nuclear- and mitochondrial-encoded subunits/ 20. Measuring redox changes to mitochondrial protein thiols using Redox DIGE/ 21.Measuring the effects of Hepatitis C proteins on mitochondrial electron transport and production of reactive oxygen species/ 22. Paraquat induced production of reactive oxygen species in brain mitochondria/ 23. The uptake and interactions of the redox cycler paraquat with mitochondria/ 24. Superoxide production by rat brain and skeletal muscle mitochondria/ 25. Quantitation, localization, and tissue specificities of mitochondrial reactive oxygen species production/ 26. The reaction mechanisms of electron transfer and superoxide generation in the cytochrome nc1 complex/ 27. Measurement of superoxide formation by mitochondrial complex I of Yarrowia lipolytica/ 28. An improved method for introducing point mutations into the mitochondrial cytochrme b gene to facilitate studying the role of cytochrome b in the formation of reactive oxygen species/ Index/ *
Singh, K. & Costello, L. ed.
Mitochondria and Cancer
Springer-Verlag 2009.1
289 pp.(H)
ISBN 0-387-84834-7
19,400円
Contents
1.Warburg and the Warburg hypothesis/ 2.The marriage of genomics, proteomics and intermediary metabolism: exciting and dangerous/ 3.Oxidative phosphorylation: the link between metabolism and cancer/ 4.Control of glycosis and oxidative phosphorylation in fast growing tumor cells/ 5.The role of citrate metabolism in prostate malignancy and other tumors/ 6.The role of mitochondria in the lipogenic/ 7.Mitochondrial apoptosis pathways in cancer/ 8.Mitochondrial tumor suppressors and neoplastic transformation/ 9.Mitochondrial DNA mutations and tumorigenesis/ 10.SDHD in parganglioma.- Mitochondria in hematogic maliagncies/ 11.Mitochondria and oncocytomas/ 12.Extracellular matrix signaling by mitochondria/ 13.Mitochondria as biomarkers of cancer/ 14.Mitochondria as target of cancer therapy/ Index/
* Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. *
Gibson, G. E. et al.
Mitochondria and Oxidative Stress in Neurodegenerative Disorders
Blackwell Pub. 2008.12
400 pp.(P)
ISBN 1-57331-713-6
13,500円
Contents
1.Mitochondrial Genetics and Neurodegenerative Diseases/ 2.Oxidant Actions and Production in Cells/ 3.Evidence for Oxidant Damage in Brains/ 4.Antioxidant Treatments/ 5.Mitochondria in Different Cell Types/ 6.Mitochondrial Function in Neurodegenerative Diseases/ 7.Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol/ 8.Changes in Mitochondria Important for Neurodegenerative Processes/ 9.Mitochondrial Effects on Genes and Gene Expression/ 10.Gene Array and Proteomic Studies/ 11.Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches/ Index/
* Our understanding of the interaction of mitochondria with other cellular organelles, with transcription, and in the ability to detect oxidative modification of macromolecules has improved significantly in the past decade. Moreover, the roles of mitochondria and oxidative stress are better defined in the pathophysiology of neurodegenerative disorders. The volume combines basic, clinical, and translational research in a forum designed to provide the most current information on aspects of mitochondrial function and its relationship to age-related neurodegenerative diseases and their treatment. *
Jeon, K. ed.
International Review of Cell and Molecular Biology, Vol.268
Academic Press 2008.7
316 pp.(H)
ISBN 0-12-374375-3
23,300円
Contents
1.Physiological Role of Ribosomal Protein S6: One of Its Kind/ 2.Molecular Domains In Epithelial Salt CellNaCl of Crustacean Salt Gland (Artemia)/ 3.Natriuretic Peptides in Vascular Physiology and Pathology/ 4.New Insights into the Cell Biology of the Insect Axonemes/ 5.New insights into the mechanism of precursor protein insertion into the mitochondrial membranes/ 6.Molecular Biology of GA Signaling in Higher Plants/ 7.Oocyte Quality and Maternal Control of Development/ Index/ *
Alberts, B. et al.
Essential Cell Biology 3rd ed.
Garland Science 2009.4
860 pp.(H)
ISBN 0-8153-4129-6
17,600円
Contents
1. Introduction to Cells/ 2. Chemical Components of Cells/ 3. Energy, Catalysis, and Biosynthesis/ 4. Protein Structure and Function/ 5. DNA and Chromosomes/ 6. DNA Replication, Repair, and Recombination/ 7. From DNA to Protein: How Cells Read the Genome/ 8. Control of Gene Expression/ 9. How Genes and Genomes Evolve/ 10. Manipulating Genes and Cells/ 11. Membrane Structure/ 12. Membrane Transport/ 13. How Cells Obtain Energy from Food/ 14. Energy Generation in Mitochondria and Chloroplasts/ 15. Intracellular Compartments and Transport/ 16. Cell Communication/ 17. Cytoskeleton/ 18. The Cell Division Cycle/ 19. Genetics, Meiosis, and the Molecular Basis of Heredity/ 20. Tissues and Cancer/ Index/
* Essential Cell Biology provides an accessible introduction to the fundamental concepts of cell biology. Its lively writing and exceptional illustrations make it the ideal textbook for a first course in cell and molecular biology. The text and figures are easy-to-follow, accurate, clear, and engaging for the introductory student. Molecular detail has been kept to a minimum in order to provide the reader with a cohesive, conceptual framework of the basic science that underlies our current understanding of biology. The Third Edition is thoroughly updated scientifically, yet maintains the academic level and size of the previous edition. The book is accompanied by a Media DVD-ROM with over 130 animations and videos, all the figures from the book, and a new self-test quizzing feature for students. *
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