Reggio, P. H. ed.
The Cannabinoid Receptors
Humana Press 2009.4
402 pp.(H)
ISBN 1-58829-712-8
15,700円
Contents
1.Cannabinoid Receptor Ligands and Structure Activity Relationships/ 2.Cannabinoid Receptor Biology/ 3.Cannabinoid Receptor Molecular Pharmacology/ 4.The Endocannabinoid System/ 5.Cannabinoid Receptor Pharmacology/ Index/ *
Lambert, D. M. ed.
Cannabinoids in Nature and Medicine
Wiley-VCH 2009.10
356 pp.(H)
ISBN 3-90639-056-X
19,400円
Contents
1. Cannabis and Endocannabinoids: "The Old Man and the Teenagers"/ 2. History of Cannabis and Its Preparations in Saga, Science, and Sobriquet/ 3. Phytocannabinoids in Cannabis sativa: Recent Studies on Biosynthetic Enzymes/ 4. On the Pharmacological Properties of delta9-Tetrahydrocannabinol (THC)/ 5. Cannabidiol -Recent Advances/ 6. From Active Ingredients to the Discovery of the Targets: The Cannabinoid Receptors/ 7. Medicinal Chemistry Endeavors around the Phytocannabinoids/ 8. Cannabis, Pain, and Sleep: Lessons from Therapeutic Clinical Trials of Sativex, a Cannabis-Based Medicine/ 9. The Toxicology of Cannabis and Cannabis Prohibition/ 10. Human Cannabinoid Pharmacokinetics/ 11. Blocking the Cannabinoid Receptors: Drug Candidates and Therapeutic Promises/ 12. Discovery and Isolation of Anandamide and Other Endocannabinoids/ 13. Biosynthetic Pathways of the Endocannabinoid Anandamide/ 14. The Multiple Pathways of Endocannabinoid Metabolism: A Zoom Out/ 15. Fatty Acid Amide Hydrolase: From Characterization to Therapeutics/ 16. Monoglyceride Lipase as an Enzyme Hydrolyzing 2-Arachidonoylglycerol/ 17. The N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA)/ 18. Genetic Polymorphisms of the Endocannabinoid System/ 19. The N-Acylethanolamine-Mediated Regulatory Pathway in Plants/ Index/ *
Davis, M. P. et al. ed.
Opioids in Cancer Pain 2nd ed.
Oxford U.P. 2009.7
456 pp.(H)
ISBN 0-19-923664-X
14,800円
Contents
* Opioids have become invaluable in modern medicine, but it is essential that they are prescribed with an understanding of the complex pharmacology behind their effectiveness. Without this, they will frequently fail to achieve their enormous potential of pain relief, minimal side effects, and improved function. In addition, opioids come with problems, including side effects such as constipation, respiratory depression, and sedation, as well as the potential for substance abuse.
* The text includes comprehensive coverage of the principles of opioid pharmacodynamics, pharmacokinetics, and pharmacogenetics. A chapter is dedicated to each of the main opioids, with topics such as structure, routes of administration, toxicity, drug interactions, and effects on organ function included within each one.
* The book concludes with several chapters dedicated to discussion of the major issues relevant to opioid use, including substance abuse, dosing strategies for acute and chronic pain, patient controlled analgesia, equianalgesia, spinal opioids, pain that doesn't respond to opioids, and the terminal phase.
* This text is the most complete and extensive work available on the use of opioids for cancer pain, and is an important reference for those clinicians treating individuals with cancer. *
Iversen, L. et al.
Dopamine Handbook
ドーパミン・ハンドブック
Oxford U.P. 2009.10
640 pp.(H)
ISBN 0-19-537303-0
15,500円
Contents
* The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders.
* Dopamine has a fundamental role in almost all aspects of behavior: from motor control to mood regulation, cognition and addiction and reward, and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades research into the role of dopamine in health and disease has been in the forefront of modern neuroscience. The Dopamine Handbook is the first single-volume publication to capture current progress and excitement in this dynamic research field. *
Jain, K. K. ed.
Drug Delivery to the Central Nervous System
Humana Press 2010.2
324 pp.(H)
ISBN 1-60761-528-2
17,500円
Contents
1. An Overview of Drug Delivery to the CNS/ 2. Receptor-Mediated Transport of Drugs Across the BBB/ 3. Disruption of Blood-Brain Barrier by Focused Ultrasound for Targeted Drug Delivery to the Brain/ 4. Prediction of Blood-Brain Barrier Penetration by Drugs/ 5. Intraparenchymal Delivery and Its Discontents/ 6. Intrathecal Drug Delivery by Implanted Pumps/ 7. Intracarotid Drug Delivery: Revisiting the Past or Looking into the Future/ 8. Vesicular Systems for Intranasal Drug Delivery/ 9. Convection-Enhanced Drug Delivery and Monitoring in a Rat Model/ 10. Intrathecal Delivery of Stem Cells to the Spinal Cord/ 11. CNS Delivery of Peptides Across the BBB Using the Dual-Artery In Situ Brain Perfusion Model/ 12. An Engineered Peptide Compound Platform Technology Incorporating Angiopep for Crossing the BBB/ 13. Adeno-Associated Virus Mediated Gene Therapy in Ischemic Stroke/ 14. Use of Mesenchymal Stem Cells for Gene Delivery to Intracranial Glioma/ 15. Convection-Enhanced Drug Delivery to the Brain/ Index/ *
Bagetta, G. et al. ed.
Advances in Neuropharmacology Vol.85
Academic Press 2009.7
504 pp.(H)
ISBN 0-12-374893-3
19,900円
Contents
1.Involvement of the prefrontal cortex in dynamical representations in problem solving situations/ 2.GLUK1 receptor antagonists and hippocampal mossy fibre function/ 3.Monoamine transporter as a target molecule for psychostimulants/ 4.Targeted lipidomics as a tool to investigate endocannabinoid function/ 5.The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs/ 6.Early postnatal stress and neural circuits underlying emotional regulation/ 7.Roles of histaminergic neurotransmission on methamphetamine-induced locomotor sensitization/ 8.Developmental exposure to cannabinoids causes subtle and enduring neurofunctional alterations/ 9.Neuronal mechanisms for pain-induced aversion: Behavioral studies using a conditioned place aversion test/ 10.Bv8/Prokineticins and their receptors: A new pronociceptive system/ 11.P2Y6-evoked microglial phagocytosis/ 12.Involvement of inflammatory mediators in neuropathic pain caused by vincristine/ 13.Intrathecal N-ethylmaleimide, a cysteine protease inhibitor, produces nociceptive behavior through inhibition of dynorphin degradation/ 14.Mechanism of allodynia in mice evoked by intrathecal morphine-3-glucuronide/ 15.Intraplantar injection of bergamot essential oil and linalool into the mouse/ 16.Effects on capsaicin-induced nociceptive response in mice/ 17.Aspect for gene-based therapy against neuropathic pain/ 18.Regulated exocytosis from astrocytes: physiological and pathological aspects/ 19.Glutamate release from astrocytic gliosomes under physiological and pathological conditions/ 20.Neurotrophic and neuroprotective actions of an enhancer of ganglioside biosynthesis/ 21.Involvement of endocannabinoid signalling in the neuroprotective effects of mGlu1 receptor antagonists in models of cerebral ischemia/ 22.NF-kappaB factors in the regulation of neuronal vulnerability/ 23.Role of Akt and ERK signaling in the neurogenesis following brain ischemia/ 24.Identification of novel pharmacological targets to minimize excitotoxic retinal damage/ 25.Differential role of PARP1 and PARP2 in post-ischemic brain damage/ 26.Oxidative stress in stroke pathophysiology: validation of hydrogen peroxide metabolism as a pharmacological target to afford neuroprotection/ Index/ *
Fischer, J. & Ganellin, C.R. ed.
Analog-Based Drug Discovery
アナログ世代の新薬発見
Wiley -VCH 2006.3
606 pp.(H)
ISBN 3-527-31257-9
25,200円
Contents
Introduction/ List of Contributors/ Abbreviations/ PART I: GENERAL ASPECTS OF ANALOGUE-BASED DRUG DISCOVERY: 1. Analogues as a Means of Discovering New Drugs/ 2. Drug Likeness and Analogue-Based Drug Discovery/ 3. Privileged Structures and Analog-Based Drug Discovery/ PART II: SELECTED EXAMPLES FROM THE ANALOGUE-BASED DRUG DISCOVERIES: 1. Development of Anti-Ulcer H2-Receptor Histamine Antagonists/ 2. Esomeprazole in the Framework of Proton-Pump Inhibitor Development/ 3. The Development of a New Proton-Pump Inhibitor: The Case History of Pantoprazole/ 4. Optimizing the Clinical Pharmacologic Properties of the HMG-CoA Reductase Inhibitors/ 5. Optimizing Antihypertensive Therapy by Angiotensin Receptor Blockers/ 6. Optimizing Antihypertensive Therapy by Angiotensin-Converting Enzyme Inhibitors/ 7. Case Study of Lacidipine in the Research of New Calcium Antagonists/ 8. Selective Beta-Adrenergic Receptor-Blocking Agents/ 9. Case Study: "Esmolol Stat"/ 10. Development of Organic Nitrates for Coronary Heart Disease/ 11. Development of Opioid Receptor Ligands/ 12. Stigmines/ 13. Structural Analogues of Clozapine/ 14. Quinolone Antibiotics: The Development of Moxifloxacin/ 15. The Development of Bisphosphonates as Drugs/ 16. Cisplatin and its Analogs for Cancer Chemotherapy/ 17. The History of Drospirenone/ 18. Histamine H1 Blockers: From Relative Failures to Blockbusters Within Series of Analogues/ 19. Corticosteroids: From Natural Products to Useful Analogues/ PART III: TABLE OF SELECTED ANALOGUE CLASSES: Index/ *
608-12 登録日 10.04.06
