Kukol, A. ed.
Molecular Modeling of Proteins
Humana Press 2008.2
390 pp.(H)
ISBN 1-58829-864-7
13,800円
Contents
1.Methodology/ 2.Free Energy Calculations/ 3.Molecular Modeling of Membrane Proteins/ 4.Protein Structure Determination/ 5.Conformational Change/ 6.Applications to Drug Design/ Index/ *
Langel, U. et al.
Introduction to Peptides and Proteins
CRC Press 2009.11
420 pp.(H)
ISBN 1-4200-6412-6
11,900円
Contents
1. Introduction/ 2. Amino Acids/ 3. Noncovalent Interactions/ 4. Structural Organization of Proteins/ 5. The Biosynthesis of Proteins/ 6. Posttranslational Modifications/ 7. Protein Folding/ 8. Intracellular Sorting of Proteins/ 9. Protein Turnover/ 10. Purification and Characterization of Proteins/ 11. Crystallography and X-Ray Diffraction/ 12. Optical Spectroscopy/ 13. Nuclear Magnetic Resonance (NMR)/ 14. Methods to Follow Protein Folding/ 15. Mass Spectrometry/ 16. Chemical Synthesis of Peptides and Proteins/ 17. Protein Engineering and Gene Silencing/ 18. Protein Ligand Interactions/ 19. Sequence Analysis and Function Prediction/ 20. Protein Structure Prediction/ 21. Proteomics/ 22. Enzymes/ 23 .Nucleic Acid-Binding Proteins/ 24. Cell Surface Receptors and Signaling/ 25. Membrane Proteins/ 26. Antibodies/ 27. Fibrous Proteins/ 28. Selected Classes of Bioactive Peptides/ 29. Misfolding-Based Diseases/ 30. Miscleavage-Based Diseases/ 31. Missequence-Based Diseases/ 32. Peptides and Proteins as Drugs/ Index/
* Human cells produce at least 30,000 different proteins. Each has a specific function characterized by a unique sequence and native conformation that allows it to perform that function. While research in this post-genomic era has created a deluge of invaluable information, the field has lacked for an authoritative introductory text needed to inform researchers and students in all of those fields now concerned with protein research. *
Nagradova, N. K. ed.
Foldase Enzymes Catalyzing Protein Folding 2nd ed.
Nova Science Pub. 2008.6
235 pp.(H)
ISBN 1-60456-389-3
17,900円
Contents
1. Foldases catalyzing the formation and isomerization of disulfide bonds in proteins/ 2. Peptidyl-prolyl cis/trans isomerases as protein folding catalysts endowed with additional functions/ 3. Foldases integrated into the structure of their cognate proteins as separate domains 4. Lipase-specific foldases/ 5. Chaperones as foldases and foldases as chaperones/ Index/
* A great deal of talent has been called upon over the past decade to try and understand the structure and the function of different types of foldases; as a result, a remarkable insight into how these enzymes work has been gained. Recently the main focus of research has begun to shift to unveiling the precise role of these folding catalysts in many different processes in which they are involved inside the cell. It is becoming increasingly clear that the cellular functions of foldases go far beyond accelerating the folding of proteins. *
Nussinov, R. & Schreiber, G. ed.
Computational Protein-Protein Interactions
CRC Press 2009.6
343 pp.(H)
ISBN 1-4200-7005-3
14,800円
Contents
1.Computational design of protein-protein interactions/ 2.Molecular Mimicry and Competitive Recruitment/ 3.Intrinsically unstructured proteins/ 4.The molecular architecture of protein-protein binding sites/ 5.Characteristic of protein-protein recognition/ 6.Protein-Protein Docking/ 7.Identification of hot spots within druggable binding regions/ 8.Hot-spot mimicry of ac cytokine receptor/ 9.Chaperone-related immune dysfunction/ 10.Recognition proteins of the innate immune system/ 11.Epitope mapping using combinatorial phage-display libraries/ 12.Identification of conserved protein complexes based on a model of protein network evolution/ 13.Interaction sites identified from sequences/ 14.Thermophilic Protein Complex Stabilized by Topological Interlinked/ 15.Protein interface recognition for structural proteomics/ 16.Strategies to search and design stabilizers of protein-protein interactions/ 17.Dynamics and allostery in protein-protein interactions/ Index/ *
Esterhouse, T. E. & Petrinos, L. B. ed.
Protein Biosynthesis
Nova Science Pub. 2009.3
358 pp.(H)
ISBN 1-60692-156-8
17,900円
Contents
1.Protein Synthesis and Ageing/ 2.Neuropeptide Biosynthesis in the Nematode Caenorhabditis Elegans: From Precursor to Bioactive Peptides/ 3.Stereochemical Mechanism of Translation Based on Intersubunit Complementaries/ 4.Trans-Translation by tmRNA and a Protein Mimicking tRNA and mRNA/ 5.Modification of mRNA Translation Initiation to Stimulate Protein Synthesis in Sepsis/ 6.Protein Synthesis in Hepatocytes of Mice as Revealed by Electron Microscopic Radioautography/ 7.Recent Advances in Label-Free Biosensors Applications in Protein Biosynthesis and HTS Screening/ 8.Translating Memories: The Role of Protein Biosynthesis in Synaptic Plasticity/ 9.Secreted Protein and Peptide Biosynthesis: Precursor Structures and Processing Mechanisms/ 10.The Effects of Temperature on Ectotherm Protein Metabolism/ 11.Protein Biosynthesis: A New Method for Functional Expression of Sodium-Dependent Glucose Transporter(SGLT) to Study Inhibition of Transport Activity and Drug Discovery/ 12.Effect of Hypoxic Conditions on Translational Control of Gene Expression/ 13.The Role of Eukaryotic Translation Initiation Factor 4E and it's Binding Factors 4E-BP1 and 4E-BP2 in body weight regulation, Ageing and Tumorigenesis/ Index/
* Protein biosynthesis (synthesis) is the process in which cells build proteins. The term is sometimes used to refer only to protein translation but more often it refers to a multi-step process, beginning with amino acid synthesis and transcription which are then used for translation. Protein biosynthesis, although very similar, differs between prokaryotes and eukaryotes. This new book presents important research in the field from around the globe. *
Zhang, A.
Protein Interaction Networks
Computational Analysis
Cambridge University Press 2009.4
292 pp.(H)
ISBN 0-521-88895-6
9,200円
Contents
1. Introduction/ 2. Experimental approaches to generation of protein-protein interaction data/ 3. Computational methods for the prediction of protein-protein interactions/ 4. Basic properties and measurements of protein interaction networks/ 5. Modularity analysis of protein interaction networks/ 6. Topological analysis of protein interaction networks Woo-chang Hwang/ 7. Distance-based modularity analysis/ 8. Graph-theoretic approaches to modularity analysis/ 9. Flow-based analysis of protein interaction networks/ 10. Statistics and machine learning based analysis of protein interaction networks Pritam Chanda and Lei Shi/ 11. Integration of gene ontology into the analysis of protein interaction networks Young-rae Cho/ 12. Data fusion in the analysis of protein interaction networks/ 13. Conclusion/ Index/
* The analysis of protein-protein interactions is fundamental to the understanding of cellular organization, processes, and functions. Recent large-scale investigations of protein-protein interactions using such techniques as two-hybrid systems, mass spectrometry, and protein microarrays have enriched the available protein interaction data and facilitated the construction of integrated protein-protein interaction networks. *
Park, S. J. & Cochran, J. R. ed.
Protein Engineering and Design
CRC Press 2009.9
416 pp.(H)
ISBN 1-4200-7658-2
15,600円
Contents
1.Phage Display Systems for Protein Engineering/ 2.Cell Surface Display Systems for Protein Engineering/ 3.Cell-Free Display Systems for Protein Engineering/ 4.Library Construction for Protein Engineering/ 5.Design and Engineering of Synthetic Binding Proteins Using Nonantibody Scaffolds/ 6.Combinatorial Enzyme Engineering/ 7.Engineering of Therapeutic Proteins/ 8.Protein Engineered Biomaterials/ 9.Protein Engineering Using Noncanonical Amino Acids/ 10.Computer Graphics, Homology Modeling, and Bioinformatics/ 11.Knowledge-Based Protein Design/ 12.Molecular Force Fields/ 13.Rotamer Libraries for Molecular Modeling and Design of Proteins/ 14.Search Algorithms/ 15.Modulating Protein Structure/ 16.Modulation of Intrinsic Properties by Computational Design/ 17.Modulating Protein Interactions by Rational and Computational Design/ 18.Future Challenges of Computational Protein Design/ Index/ *
DeLucas, L.
Membrane Protein Crystallization
Current Topics in Membranes Vol.63
Academic Press 2009.6
336 pp.(H)
ISBN 0-12-374987-5
21,000円
Contents
1.Introduction to the Crystallization of Biological Macromolecules/ 2.Challenges of Membrane Protein Crystallization/ 3.Cell Free Production of Membrane Proteins/ 4.In Vitro Synthesis of Post-translationally Modified Membrane Proteins/ 5.Novel Rhodobactar Membrane Protein Expression Factory/ 6.Detergent selection and optimization in membrane protein crystallization/ 7.Novel Lipids for Membrane Protein Crystallization/ 8.Bicelle Membrane Protein Crystallization/ 9.Novel Approaches for Membrane Protein Crystallization/ 10.Tools to Enhance Membrane Protein Crystallization/ 11.Advances in Microfluidic Membrane Protein Crystallization Techniques/ 12.Crystallization Strategies Used for Photosystem I and its Complexes/ 13.a-barrel Membrane Protein Crystallization/ 14.Membrane Proteins: the New Soluble Proteins/ Index/ *
Jensen, K. ed.
Peptide and Protein Design for Biopharmaceutical Applications
John Wiley & Sons 2009.11
306 pp.(H)
ISBN 0-470-31961-5
17,400円
Contents
1. Introduction/ 2. Computational Approaches in Peptide and Protein Design: An Overview/ 3. Aspects of Peptidomimetics/ 4. Design of Cyclic Peptides/ 5. Carbohydrates in Design of Peptides and Proteins/ 6. De Novo design of proteins/ 7. Design of insulin variants for improved treatment of diabetes/ Index/
* Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create ‘ailor-made’peptides and proteins with improved pharmacological properties. *
637-33 登録日 09.11.15
