Pasqualini, R. & Arap, W. ed.
Protein Discovery Technologies
Taylor & Francis 2009.7
250 pp.(H)
ISBN 0-8247-5468-9
16,800円
Contents
1. Discovery of Vascular Permeability Factor (VPF, VEGF, VPF/VEGF, VEGF-A165)/ 2. Tumor Necrosis Factor and Its Family Members/ 3. Blood-Brain Barrier Models for Investigating CNS Pathologies/ 4. Identification of Activation of Latent TGF as Principal In Vivo Function of Integrin av 6/ 5. Purification of Basic Fibroblast Growth Factor by Heparin Affinity/ 6. How It Came to Pass that Interferon Was Used as an Angiogenesis Inhibitor/ 7. Use of Phage Display to Discover Inhibitors of Cell Migration/ 8. Combinatorial Mapping of Vascular Zip Codes by In Vivo Phage Display/ 9. Chasing Elusive Cellular Prion Protein Receptor/ 10. Discovery of Molecular Chaperone GRP78 and GRP94 Inducible by Endoplasmic Reticulum Stress/ 11. Origin of Sphingomyelin Pathway/ 12. Endotoxin-Induced Myocarditis: A New Pathophysiological Entity in Systemic Inflammatory Response Syndrome/ 13. Discovery of DOCK180 Superfamily of Exchange Factors/ 14. Discovery of Extracellular Matrix Degradome as Novel Endogenous Regulators of Angiogenesis and Tumor Growth/ 15. RING Finger Proteins as E3 Ubiquitin Ligases/ 16. Discovery of Chemical Nature of Cross-Links in Collagen: A Personal Retrospective/ 17. Discovery of SPARC as Prototype for Matricellular Proteins/ Index/ *
Burgess, R. ed.
Guide to Protein Purification 2nd ed.
たんぱく質精製法 第２版
Academic Press 2009.11
912 pp.(P)
ISBN 0-12-374978-6
10,800円
Contents
1. Strategies and Considerations for Protein Purifications/ 2. Bioinformatics in Planning a Protein Purification/ 3. Preparing a Protein Purification Summary Table/ 4. Setting up a Laboratory/ 5. Buffers: Principle and Practice/ 6. Measurement of Enzyme Activity/ 7. Quantitation of Protein/ 8. Maintaining Protein Stability/ 9. Strategy for Choosing and Expression System/ 10. Bacterial Expression Systems/ 11. Yeast Expression Systems/ 12. Baculovirus-Insect Cell Expression Systems/ 13. Mammalian Expression Systems/ 14. Expression of Tagged Proteins/ 15. Re-folding of Solubilized Inclusion Body Proetin/ 16. Preparation of Biological Extract/ Index/ *
Blaskovich, M. A.
Handbook on Syntheses of Amino Acids
General Routes to Amino Acids
（アミノ酸合成便覧）
ACS 2010.2
1304 pp.(H)
ISBN 0-8412-7219-0
22,000円
Contents
1. Introduction/ 2. Synthesis of Racemic a-Amino Acids: Amination and Carboxylation/ 3. Synthesis of Racemic -Amino Acids: Introduction of the Side Chain/ 4. Synthesis and Elaboration of Didehydro Amino Acids/ 5. Synthesis of Optically Active a-Amino Acids: Extension of Achiral Methods - Amination and Carboxylation Reactions/ 6. Synthesis of Optically Active Amino Acids: Extension of Achiral Methods - Introduction fo the Side Chain to Acyclic Systems/ 7. Synthesis of Optically Active a-Amino Acids: Alkylation of Cyclic Chiral Templates/ 8. Synthesis of Optically Active a-Amino Acids: Opening of Small Ring Systems/ 9. Synthesis of Optically Active a-Amino Acids: Elaboration of Amino Acids Other than Serine/ 10. Synthesis of Optically Active -Amino Acids: Elaboration of Serine/ 11. Synthesis of -, -, -, and -Amino Acids/ 12. Modifications of Amino Acids: Resolution, N-Alkylation, N-Protection, Amidation and Coupling/ Index/ *
Hinterdorfer, P. & van Oijen, A. ed.
Handbook of Single-Molecule Biophysics
単一分子の生物物理ハンドブック
Springer-Verlag 2009.7
626 pp.(H)
ISBN 0-387-76496-8
32,400円
Contents
* この十年間で数多くの新しい生物物理実験法の進歩が見られました。本ハンドブックは、蛍光検出法、原子間力顕微鏡法、光と磁気トラッピング法を含む単一生物分子のモニターと操作を実施する実験技術を解説します。超解像度や機能的画像法における単一分子技法の利用法、折りたたみ、タンパク質やDNAの高分子物理学、酸素と生化学、生体膜中の単一分子、生体細胞の単一分子技法のような生物分子の物理学的特性研究、単一分子生物物理学とナノサイエンスとの統合などが討議されます。
1. Single-molecule fluorescence tracking/ 2. Single molecule studies in the membrane/ 3. Single-molecule imaging in live cells/ 4. Superresolution imaging/ 5. Fluorescence Resonance Energy Transfer/ 6. Single-molecule enzymology/ 7. Rotary proteins/ 8. Fluorescence Correlation Spectroscopy/ 9. Advanced Concepts of Fluorescence Fluctuation Spectroscopy/ 10. Nucleic-acid analysis at the single-molecule level/ 11. Nanopores: Geneneration and Single-Molecule Applications/ 12. Optical trapping/ 13. Magnetic tweezing/ 14. Protein/DNA unfolding/ 15. Single molecule recognition/ 16. Nano-scale AFM imaging/ 17. High Speed AFM/ 18. Recognition imaging/ 19. Atomic force microscopy of protein-protein interactions/ 20. A New Approach to Analysis of Single Molecule Force Measurements/ 21. Single Molecule Recognition: Extracting Information from Individual Binding Events and Their Correlation/ Index/ *
Hughes, A. B. ed.
Amino Acids, Peptides and Proteins in Organic Chemistry Vol.2
Modified Amino Acids, Organocatalysis and Enzymes
（有機化学におけるアミノ酸、ペプチド、タンパク質 第２巻：変性アミノ酸、有機触媒作用、酵素）
Wiley-VCH 2009.11
705 pp.(H)
ISBN 3-527-32098-9
22,400円
Contents
* 本シリーズは、有機化学および生化学におけるアミノ酸、ペプチド、タンパク質を詳細に解説し、アミノ酸化学のひとつのベンチマークたることを目的としています。国際的に実績のある研究者が編集を担当し、アミノ酸と、その多量体型であるペプチドおよびタンパク質について、発生から用途、応用まで、包括的な議論を提供します。実験手順の解説も収録しました。
1. Synthesis and Chemistry of Modified Amino Acids/ 2. Amino Acid Organocatalysis/ 3. Enzymes/ Index/ *
Herschlag , D. ed.
Biophysical, Chemical, and Functional Probes of RNA Structure, Interactions and Folding Part A
(Methods in Enzymology Vol.468)
RNA構造と折り畳への生物物理的アプローチ
Academic Press 2009.11
496 pp.(H)
ISBN 0-12-374399-0
19,800円
Contents
1. Equilibrium hydroxyl radical footprinting/ 2. Bench-top time-resolved hydroxyl radical footprinting/ 3. Analysis of hydroxyl radical footprinting gels 'SAFA'/ 4. Kinetic modeling of reaction pathways from hydroxyl radical data/ 5. "BABE" mapping of protein/RNA position/ 6. Multiplexed?.(MOHCA)/ 7. SHAPE/ 8. "In-line Probing" / 9. NAIM/ 10. Other NAIM/ 11. Purification of T7 RNA Polymerase/ 12. Purification of T4 RNA ligase/ 13. In vitro transcription of RNA/ 14. 32P-labeling of RNA/ 15. Fluorescent labeling of RNAs/ 16. Assembly of complex RNAs by �]Moore-Sharp' ligations/ 17. Assembly of complex RNAs by �]Moore-Sharp' ligations/ 18. General considerations for smFRET with RNA samples/ 19. Ion counting/ 20. ASAXS/ 21. NLPB/ 22. smNLPB/ 23. Gel mobility mapping of junction structure/ 24. Temperature gradient gels/ 25. Melting studies/ 26. Co-transcriptional folding studies/ 27. Activity assays to follow folding processes/ 28. 2AP fluorescence/ 29. EPR measurements of RNA dynamics/ 30. EPR measurements of RNA dynamics/ 31. FPA measurements of RNA dynamics/ 32. EPR methods to study specific metal ion binding sites in RNA/ 33. Thermodynamic study of site-specific metal ion binding sites in RNA/ 34. Oligonucleotide hybridization studies of RNA folding pathways/ 35. Native gel shifts/ 36. Tiling arrays to assess RNA structure/ 37. EPR distance measurements in RNA/ 38. RNA folding in vivo/ 39. Cleavage of RNAs with �]restriction DNAzymes'/ Index/
* This MIE volume provides laboratory techniques that aim to predict the structure of a protein which can have tremendous implications ranging from drug design, to cellular pathways and their dynamics, to viral entry into cells. *
Durante, P. & Colucci, L. ed.
Handbook of Molecular Chaperones
Roles, Structures and Mechanisms
Nova Science Pub. 2010.3
567 pp. (H)
ISBN 1-60876-366-8
40,200円
Contents
1. Molecular Chaperones of the Endoplasmic Reticulum/ 2. Type III Secretion Chaperones: A Molecular Toolkit for all Occasions/ 3. Advances in Heat Shock Proteomics: Towards a Better Understanding of the Physiology and Pathophysiology of Molecular Chaperones/ 4. System Specific Chaperones for Membrane Redox Enzyme Maturation in Bacteria/ 5. Role of Molecular Biology in Molecular Imaging/ 6. Yeast Protein Aggregates, Containing Chaperones and Glucose Metabolism Enzymes/ 7. Structure and Multiple Functions of Cyclophilin 40: A Divergent Loop Cyclophilin/ 8. Free-Living Protists as a Model for Studying Heat Shock Proteins in the Cell/ 9. Quality Control in the Secretory Pathway/ 10. Structure, Properties and Multiple Functions of Human Small Heat Shock Protein HspB8 (Hsp22, H11 Protein Kinase or E2IG1)/ 11. Small Stress Proteins and their Therapeutic Potential/ 12. The eukaryotic chaperonin CCT (TRiC): Structure, Mechanisms of Action and Substrate Diversity/ 13. The role of molecular chaperones in plant stress response/ 14. Chaperone Activity of Intrinsically Disordered Proteins/ 15. Fluorescence Study on Aggregation of _-Crystallin and Insulin/ 16. The Induction of Hepatic Heat Shock Protein 27 and 70 by an Anti-Hepatitis Drug-Bicyclol and its Role in Protection against Liver Injury/ 17. Plant Heat Shock Proteins as Molecular Chaperones in Normal and Stress Conditions/ 18. Different Mechanisms Responsible for Stress Resistance Operate in the Same Insect Order (Diptera)/ 19. Bi-Directional Hsp Response in Homeothermic Livestock/ 20. The Chaperonin Containing T-complex Polypeptide: Do Monomeric Subunits Have Discrete Individual Functions?/ 21. Evidence for In Vivo Phosphorylation of Hsp26 from Saccharomyces Cerevisiae/ Index/
* Molecular chaperones are a ubiquitous class of proteins that play important roles in protein folding and in the protection of cells from several stresses associated with the disruption of three native dimensional structures of proteins. The most important of these proteins are the so-called heat shock proteins (HSPs), also known as stress proteins. This book examines some of the biological aspects of this intriguing family of proteins that are important for consideration of the "proteiomics of HSPs." This book also reviews current research on protein folding in the endoplasmic reticulum (ER) and the functions of ER-resident molecular chaperones in protein folding in the ER. *
637-34 登録日 10.05.11
