Karshikoff, A.
Non-Covalent Interactions in Proteins
Imperial College Press 2006.12
333 pp. (H)
ISBN 1-86094-707-7
11,000円
Contents
1.Overview of Protein Structural Elements and Basic Definitions/ 2.Non-Covalent Interactions and Structure-Function Relationships in Proteins/ 3.Observation of van der Waals Interactions/ 4.Nature of van der Waals Interactions/ 5.Potential Functions for Application in Proteins/ 6.Approximation for Polyatomic Systems/ 7.Nature of Hydrogen Bonds/ 8.Geometry and Strength of Hydrogen Bonds/ 9.Hydrogen Bonds in Proteins/ 10.Hydrogen Bonds and Protein Stability/ 11.Nature of Hydrophobic Interactions, Pseudo Forces/ 12.Water/ 13.Hydrophobic Effect / 14.Hydrophobic Interactions in Proteins/ 15.Ion-Solvent Interactions/ 16.Calculation of Electrostatic Interactions in Proteins/ 17.Why Does One Need to Know Ionisation Equilibria? / 18.Basic Definitions / 19.Factors Determining Ionisation Equilibria in Proteins/ 20.Combinatorial Problem/ 21.Cooperative Ionisation/ 22.Allocation Variation of Polar Hydrogen Atoms/ 23.Examples for pH-Dependent Hydrogen Bonding/ 24.Conformational Flexibility Involving Non-Hydrogen Atoms/ 25.Definitions/ 26.Unfolding Induced by pH/ 27.Modeling of Unfolded Proteins/ 28.Thermal Stability of Proteins/ *
Meyers, R. A. ed.
Proteins Vol.1 & 2
From Analytics to Structural Genomics
タンパク質：分析から構造ゲノミクスまで 全2巻
Wiley -VCH 2006.12
1218 pp.(H) 2 vols set
ISBN 3-527-31608-6
57,000円
Contents
* 本書は全16巻の百科事典 ﾒEncyclopedia of Molecular Cell Biology and Molecular Medicineﾓからタンパク質研究に関わる記事をまとめたリファレンスです。
* 3人のノーベル賞受賞者が寄稿しており、タンパク質の構造、モデリング、発現、分析などタンパク質研究の幅広いトピックをまとめています。
Contents:
VOLUME 1 Pt.1.Structure and Function : 1.Macromolecules, X-Ray Diffraction of Biological/ 2.Protein NMR Spectroscopy/ 3.Electron Microscopy of Biomolecules/ 4.Circular Dichroism in Protein Analysis/ 5.Protein Structure Analysis: High-throughput Approaches/ 6.Aggregation, Protein/ 7.Prions/ 8.Alzheimerﾕs Disease/ 9.Chaperones, Molecular/ 10.Motor Proteins/ 11.DNA-Protein Interactions/ Pt.2.Modelling and Design : 12.Protein Modeling/ 13.Synthesis of Peptide Mimetics and their Building Blocks/ 14.Design and Application of Synthetic Peptides/ 15.Synthetic Peptides: Chemistry, Biology, and Drug Design/ Pt.3.Expression, Synthesis and Degration : 16.Ribosome, High Resolution Structure and Function/ 17.Ubiquitin-Proteasome System for Controlling Cellular Protein Levels/ 18.Plant-based Expression of Biopharmaceuticals/ 19.Cell-free Translation Systems/
VOLUME 2 Pt.1.Analytical Techniques : 1.HPLC of Peptides and Proteins/ 2.Protein Purification/ 3.Gel Electrophoresis, 2D-Difference/ 4.Proteomics/ 5.Mass Spectrometry-based Methods of Proteome Analysis/ 6.Protein Microarrays/ 7.Informatics (Computational Biology)/ 8.Nucleic Acid and Protein Single Molecule Detection and Characterization/ 9.Footprinting Methods to Examine the Structure and Dynamics of Proteins/ Pt.2.Signalling and Regulation : 10.Biological Regulation by Protein Phosphorylation/ 11.Intracellular Signaling in Cancer/ 12.Receptor Biochemistry/ 13.Signal Transduction Mediated by Heptahelical Receptors and Heterotrimeric G Proteins/ 14.Growth Factors/ 15.Cytokines: Interleukins/ 16.Viral Inhibitors and Immune Response Mediators: The Interferons/ 17.Molecular Mediators: Cytokines/
* With three Nobel Laureates contributing to this invaluable collection of high-quality articles, carefully selected from the highly praised R.A. Meyer's Encyclopedia, these two volumes cover a wide range of topics in protein research. Clearly divided into sections on structure, modeling, expression, analysis and others, the chapters are designed to aid readers of all levels of expertise. Each chapter includes a glossary of the most important keywords, a concise summary of the article concerned and comprehensive references for further reading. Similarly, the uniform structure of the articles makes them very easy to use, resulting in a ready reference for molecular and cell biologists, biochemists, biophysicists, and biotechnologists, as well as those working in the pharmaceutical and biotechnological industries. *
Frey, P. A. & Hegeman, A. D.
Enzymatic Reaction Mechanisms
Oxford U.P. 2007.1
848 pp. (H)
ISBN 0-19-512258-5
28,900円
Contents
1. Enzymes and Catalytic Mechanisms/ 2. Kinetics of Enzymatic/ 3. Coenzymes I: Organic Coenzymes/ 4. Coenzymes II: Metallic Coenzymes/ 5. Enzyme Inhibition/ 6. ACYL Group Transfer: Proteases/ 7. Isomerization/ 8. Decarboxylation and Carboxylation/ 9. Addition and Elimination/ 10. Phosphotransfer AND NucleotidylTransfer / 11. ATP-Dependent Synthetases and Lifases/ 12. Glycosyl Group Transferases/ 13. Nitrogen and Sulfur Transferases/ 14. Carbon-Carbon Condensation and Cleavage/ 15. Alkyltransferases/ 16. Oxidoreductases/ 17. Oxidases and Oxygenases/ 18. Complex Enzymes/
* This text by Perry A. Frey and Adrian D. Hegeman accomplishes this feat, producing the long-awaited replacement for Walshs classic text. *
Kyte, J.
Structure in Protein Chemistry 2nd ed.
Garland Science 2007.4
898 pp. (H)
ISBN 0-8153-3867-8
18,500円
Contents
1. Purification/ 2. Electronic Structure/ 3. Sequences of Polymers/ 4. Crystallographic Molecular Models/ 5. Noncovalent Forces/ 6. Atomic Details/ 7. Evolution/ 8. Counting Polypeptides/ 9. Symmetry/ 10. Chemical Probes of Structure/ 11. Immunochemical Probes of Structure/ 12. Physical Measurements of Structure/ 13. Folding and Assembly/ 14. Membranes/ Index/
* The second edition of Structure in Protein Chemistry showcases the latest developments and innovations in the field of protein structure analysis and prediction. *
Fields, G.B.
Peptide Characterization and Application Protocols
Humana Press 2007.4
356 pp. (H)
ISBN 1-58829-550-8
13,900円
Contents
1: HPLC Analysis and Purification of Peptides/ 2: Identification of Proteins Based on MS/MS Spectra and Location of Post-translational Modifications/ 3: Determination of Phosphorylated and O-glycosylated Sites by Chemical Targeting (CTID) at Ambient Temperature/ 4: Synthesis, Biosynthesis, and Characterization of Transmembrane Domains of a G Protein-Coupled Receptor/ 5: Application of Topologically Constrained Mini-Proteins as Ligands, Substrates, and Inhibitors/ 6: Proteolytic Profiling of the Extracellular Matrix Degradome/ 7: S-Amyloid Protein Aggregation Inhibition/ 8: Radiometal-labeled Somatostatin Analogues for Applications in Cancer Imaging and Therapy/ 9: Cell Penetrating Proline Rich Peptidomimetics/ 10: Peptide-Mediated Targeting of Liposomes to Tumor Cells/ 11: Peptide-Mediated Delivery of Nucleic Acids into Mammalian Cells/ 12: Broth Microdilution Antibacterial Assay of Peptides/ 13: Depsipeptide Synthesis/ *
Wink, M. ed.
An Introduction to Molecular Biotechnology
Molecular Fundamentals, Methods and Applications in Modern Biotechnology
John Wiley & Sons 2006.9
768 pp. (P)
ISBN 3-527-31412-1
13,000円
Contents
Preface / List of Contributors / Abbreviations / Colour Plates / Part I: Fundamentals of Cellular and Molecular Biology. 1 The Cell as the Basic Unit of Life / 2 Structure and Function of Cellular Macromolecules / 3 Structure and Function of a Cell / 4 Biosynthesis and Function of Macromolecules (DNA, RNA, and Proteins) / 5 Distributing Proteins in the Cell (Protein Sorting) / 6 Diversity of Organisms / Part II: Standard Methods in Molecular Biotechnology. 7 Isolation and Purification of Proteins / 8 Peptide and Protein Analysis with Electrospray Tandem Mass Spectrometry / 9 Isolation of DNA and RNA / 10 Chromatography and Electrophoresis of Nucleic Acids / 11 Hybridization of Nucleic Acids / 12 The Use of Enzymes in the Modification of Nucleic Acids / 13 Polymerase Chain Reaction (PCR) / 14 DNA Sequencing / 15 Cloning Procedures / 16 Expression of Recombinant Proteins / 17 The Patch Clamp Method / 18 Cell Cycle Analysis / 19 Techniques in Microscopy / 20 Laser Applications / Part III:Key Topics. 21 Genomics / 22 Functional Genomics / 23 Protein�弃rotein and Protein�廛NA Interaction / 24 Bioinformatics / 25 Drug Research / 26 Drug Targeting and Prodrugs / 27 Molecular Diagnostics in Medicine / 28 Recombinant Antibodies and Phage Display / 29 Genetically Modified Mice (Transgenic and Knockout) and their Impact on Medicine / 30 Gene Therapy: Strategies and Vectors / 31 Modified DNA, PNA, and Applications in Medicine and Biotechnology / 32 Plant Biotechnology / 33 Biocatalysis in the Chemical Industry / Part IV: Biotechnology in Industry. 34 Industrial Application (Biotech Industry, Markets and Opportunities) / 35 Patents in the Pharmaceutical Biotechnology Industry: Legal and Ethical Issues / 36 Drug Approval in the European Union and United States / 37 The Emergence of a Biotechnology Industry / 38 The 101 of Founding a Biotech Company / 39 Marketing / Glossary / Subject Index / **
* Written by exceptionally experienced experts from one of the world's major biotech regions, the Heidelberg area, the authors come from academia, such well-known research centers as the German Cancer Research Center, and biotech companies. A very detailed introduction to the fundamentals in molecular and cell biology is followed by an overview of standard techniques applied in molecular biotechnology -- including chromatography and electrophoresis, cloning techniques, gene expression systems, immunological methods, labeling of proteins and in situ-techniques, microscopy and laser systems. The third part then focuses on the key topics of molecular biotechnology, ranging from functional genomics, proteomics and bioinformatics to drug targeting, recombinant antibodies, structural biology, gene therapy and knock mice. The whole is rounded off by a section on biotechnology in industry dealing with patenting issues, company foundation and market opportunities. On over 800 pages this book provides students and professionals in life sciences, pharmacy and biochemistry with all they need to know about molecular biotechnology. *
650-30 登録日 07.06.12
